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Ava
Udvadia
Assistant
Professor
Biological Sciences, UWM
Phone: (414)
382-1750 / 229-3404
Fax: (414)
382-1705
E-Mail:
Web
Site: WATER
Profile Page
Great
Lakes WATER Institute
600 E. Greenfield Ave.
Milwaukee, WI 53204 |
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Research Interests
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My
research interests center on understanding the molecular and cellular
mechanisms of central nervous system (CNS) development and regeneration.
Currently I am focusing on two specific aspects of CNS development
-- regulation of axon growth and neuronal cell fate specification
from an initial progenitor cell population. These two aspects of
CNS development are also important in the regenerating nervous system,
which requires the re-initiation of axon growth in damaged nerves
and/or the replacement of neurons that have undergone cell death
in response to damage. I am using the zebrafish as a model organism
to address the following questions regarding nervous system development
and regeneration: 1) how do mechanisms regulating axon growth and
cell fate specification differ between the developing and regenerating
nervous system? and 2) what are the differences between neurons or
nervous systems that are capable of regeneration and those that are
not? | |
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Education
| • | B.S.
University of Michigan, Cell and Molecular Biology, 1989 |
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| • | Ph.D.
Duke University, Molecular Cancer Biology, 1995 |
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| • | Post-doctoral
Fellow Duke University, Neuroscience, 1996-2001 |
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Selected Publications
| • | Ava
J. Udvadia. Identification of Ganglion Cell-Specific Progenitor Cells
In Developing Zebrafish Retina. Submitted. |
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| • | Linney,
E., and Udvadia, A. J., 2004. Construction and detection of fluorescent
germ-line transgenic zebrafish. In "Methods in Molecular Medicine" (H.
Schatten, Ed.), Vol. 254, Germ Cell Protocols: Molecular Embryo Analysis,
Live Imaging, Transgenesis, and Cloning, pp. 271-288. Humana Press
Inc., Totowa, NJ. |
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| • | Ava
J. Udvadia and Elwood Linney, 2003. Windows into Development: Historic,
Current and Future Perspectives on Transgenic Zebrafish. Developmental
Biology, 256: 1-17. |
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| • | Ava
J. Udvadia, Reinhard W. Köster, and J. H. Pate Skene, 2001. GAP-43
Promoter Elements in Transgenic Zebrafish Reveal a Difference in Signals
for Axon Growth During CNS Development and Regeneration. Development,
128: 1175-1182. |
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| • | Sarah
B. Kennet*, Ava J. Udvadia*, and Jonathan M. Horowitz, 1997. Sp3 Encodes
Multiple Proteins That Differ in Their Capacity to Stimulate or Repress
Transcription. Nucleic Acids Research, 25: 3110-3117.
*first and second authors contributed equally to this work. |
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| • | Jonathan
M. Horowitz and Ava J. Udvadia, 1995. Regulation of Transcription by
the Retinoblastoma (Rb) Protein. Molecular and Cellular Differentiation,
3: 275-314. |
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