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Michael
J. Carvan
Assistant
Scientist
Great Lakes WATER Institute, UWM
Phone: (414)
382-1706
Fax: (414)
382-1705
E-Mail:
Web
Site: WATER
Profile Page
Great
Lakes WATER Institute
600 E. Greenfield Ave.
Milwaukee, WI 53204 |
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Research Interests
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Research
currently underway in the laboratory takes advantage of the power
of the zebrafish genetic model system to explore the mechanism(s)
by which xenobiotics (e.g. environmental chemicals, pesticides, pharmaceuticals)
induce disease in both fish and humans, and to identify genes that
influence sensitivity and resistance to chemical exposure. | |
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Education
| • | Ph.D. Veterinary Anatomy and
Public Health, Texas A&M University College of Veterinary Medicine, 1993 |
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| • | M.S. Biological Oceanography,
University of Miami Rosenstiel School of Marine and Atmospheric Science,
1988 |
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| • | B.S. Marine Biology, University
of North Carolina at Wilmington, 1985 |
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Selected Publications
| • | King
Heiden, T., M.J. Carvan III, R.J. Hutz. 2006. Inhibition of follicular
development, vitellogenesis, and serum 17β estradiol concentrations
in zebrafish following chronic, sublethal dietary exposure to 2,3,7,8,-tetrachlorodibenzo-p-dioxin.
Accepted for publication in Toxicological Sciences, Advanced Access
Publication, December 30, 2005. [PubMed] |
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| • | King
Heiden, T., R.J. Hutz, M.J. Carvan III. 2005. Accumulation, tissue
distribution, and maternal transfer of dietary 2,3,7,8-dibenzo-p-dioxin:
impacts on reproductive success of zebrafish. Toxicological Sciences
87:497-507, Advanced Access Publication, May 18, 2005. [PubMed] |
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| • | Carvan,
M.J., III, E. Loucks, D.N. Weber, and F.E. Williams. 2004. Ethanol effects
on the developing zebrafish: neurobehavior and skeletal morphogenesis. Neurotoxicology
and Teratology 26:757-768. [PubMed] |
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| • | Loucks,
E. and M.J. Carvan III. 2004. Strain-dependent effects of developmental
ethanol exposure in zebrafish. Neurotoxicology and Teratology 26:745-55.
[PubMed] |
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| • | Dasmahapatra,
A.K., H.L. Doucet, C. Bhattacharyya, and M.J. Carvan III. 2001. Developmental
expression of alcohol dehydrogenase (ADH3) in zebrafish (Danio rerio).
Biochemical and Biophysical Research Communications 286:1082-1086. [PubMed] |
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| • | Carvan,
M.J., III, D.M. Sonntag, C.B. Cmar, R.S. Cook, M.A. Curran, and G.L.
Miller. 2001. Oxidative stress in zebrafish cells: Potential utility
of transgenic zebrafish as a deployable sentinel for site hazard ranking.
The Science of the Total Environment 274:183-196. [PubMed] |
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| • | Carvan,
M.J., III, T.P. Dalton, G.W. Stuart, and D.W. Nebert. 2000. Transgenic
zebrafish as sentinels for aquatic pollution. Annals of the New York
Academy of Science, 919:133-147. [PubMed] |
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| • | Carvan,
M.J.,III, W.A. Solis, L. Gedamu, and D.W. Nebert. 2000. Activation of
transcription factors in zebrafish cell cultures by environmental pollutants.
Archives of Biochemistry and Biophysics 376:320-327. [PubMed] |
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| • | Dalton,
T.P., W.A. Solis, D.W. Nebert, and M.J. Carvan III. 2000. Characterization
of MTF-1 transcription factor from zebrafish and trout cells. Comparative
Biochemistry and Physiology 126:325-335. [PubMed] |
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Book
Chapters
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Postlethwait,
J, V. Ruotti, M.J.
Carvan,
P.J. Tonellato. 2004 Automated Analysis of Conserved Syntenies
for the Zebrafish Genome, pp 255-271. In H. Detrich, III,
et al. eds., The
Zebrafish: Genetics, Genomics and Informatics (Methods in Cell
Biology 77),
Elsevier. |
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Carvan,
M.J., III,
and Busbee, D. 2003. Mechanisms of aromatic hydrocarbon
toxicity: Implications for cetacean morbidity and mortality,
pp 429-457. In J.G. Vos et al. eds., Toxicology of Marine
Mammals. Taylor and
Francis Publishers, London, UK. |
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Carvan,
M.J., S.D. Miller and D.L. Busbee. 2002. Cellular
and Molecular Investigations Utilizing a Bottlenose Dolphin Epithelial
Cell Line, pp 313-327. In C. Pfeiffer, ed. Molecular
and Cell Biology of Marine Mammals, Krieger Publishing Co.,
Inc, Mellbourne, FL. |
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