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Michael J. Carvan III
Associate Scientist
Phone: (414) 382-1706
Fax: (414) 382-1705
E-Mail:
Web Site: http://www.uwm.edu/People/carvanmj
Great Lakes WATER Institute
600 E. Greenfield Ave.
Milwaukee, WI 53204 |
Research Interests
Research currently underway in the laboratory takes advantage of the power of the zebrafish genetic model system to explore the mechanism(s) by which xenobiotics (e.g. environmental chemicals, pesticides, pharmaceuticals) induce disease in both fish and humans, and to identify genes that influence sensitivity and resistance to chemical exposure.
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Education
- Ph.D. Veterinary Anatomy and Public Health, Texas A&M University College of Veterinary Medicine, 1993
- M.S. Biological Oceanography, University of Miami Rosenstiel School of Marine and Atmospheric Science, 1988
- B.S. Marine Biology, University of North Carolina at Wilmington, 1985
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Publications
- King Heiden, T., M.J. Carvan III, R.J. Hutz. 2006. Inhibition of
follicular development, vitellogenesis, and serum 17ß estradiol
concentrations in zebrafish following chronic, sublethal dietary exposure to
2,3,7,8,-tetrachlorodibenzo-p-dioxin. Accepted for publication in
Toxicological Sciences, Advanced Access Publication, December 30, 2005. [PubMed]
- King Heiden, T., R.J. Hutz, M.J. Carvan III. 2005. Accumulation,
tissue distribution, and maternal transfer of dietary
2,3,7,8-dibenzo-p-dioxin: impacts on reproductive success of zebrafish.
Toxicological Sciences 87:497-507, Advanced Access Publication, May 18,
2005. [PubMed]
- Carvan, M.J., III, E. Loucks, D.N. Weber, and F.E. Williams. 2004. Ethanol
effects on the developing zebrafish: neurobehavior and skeletal morphogenesis. Neurotoxicology
and Teratology 26:757-768. [PubMed]
- Loucks, E. and M.J. Carvan III. 2004. Strain-dependent effects of developmental
ethanol exposure in zebrafish. Neurotoxicology and Teratology 26:745-55. [PubMed]
- Dasmahapatra, A.K., H.L. Doucet, C. Bhattacharyya, and M.J. Carvan III. 2001. Developmental expression of alchohol dehydrogenase (ADH3) in zebrafish (Danio rerio). Biochemical and Biophysical Research Communications 286:1082-1086.
[PubMed]
- Carvan, M.J., III, D.M. Sonntag, C.B. Cmar, R.S. Cook, M.A. Curran, and G.L. Miller. 2001. Oxidative stress in zebrafish cells: Potential utility of transgenic zebrafish as a deployable sentinel for site hazard ranking. The Science of the Total Environment 274:183-196.
[PubMed]
- Carvan, M.J., III, T.P. Dalton, G.W. Stuart, and D.W. Nebert. 2000. Transgenic zebrafish as sentinels for aquatic pollution. Annals of the New York Academy of Science, 919:133-147.
[PubMed]
- Carvan, M.J.,III, W.A. Solis, L. Gedamu, and D.W. Nebert. 2000. Activation of transcription factors in zebrafish cell cultures by environmental pollutants. Archives of Biochemistry and Biophysics 376:320-327.
[PubMed]
- Dalton, T.P., W.A. Solis, D.W. Nebert, and M.J. Carvan III. 2000. Characterization
of MTF-1 transcription factor from zebrafish and trout cells. Comparative Biochemistry
and Physiology 126:325-335.
[PubMed]
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