Michael J. Carvan III

	Michael J. Carvan III Associate Scientist Phone: (414) 382-1706 Fax: (414) 382-1705 E-Mail: Web Site: http://www.uwm.edu/People/carvanmj Great Lakes WATER Institute 600 E. Greenfield Ave. Milwaukee, WI 53204
Research Interests Research currently underway in the laboratory takes advantage of the power of the zebrafish genetic model system to explore the mechanism(s) by which xenobiotics (e.g. environmental chemicals, pesticides, pharmaceuticals) induce disease in both fish and humans, and to identify genes that influence sensitivity and resistance to chemical exposure.

Education Ph.D. Veterinary Anatomy and Public Health, Texas A&M University College of Veterinary Medicine, 1993 M.S. Biological Oceanography, University of Miami Rosenstiel School of Marine and Atmospheric Science, 1988 B.S. Marine Biology, University of North Carolina at Wilmington, 1985

Publications Kusik, B.W., M.J. Carvan III, A.J. Udvadia. 2008. Detection of Mercury in Aquatic Environments using EPRE Reporter Zebrafish. Marine Biotechnology 10:750-757. Carvan, M.J. III, J.P. Incardona, M.L. Rise. 2008. Meeting the challenges of aquatic vertebrate ecotoxicology. Bioscience 58:1015-1025. Aleström, P., G. Begemann, M.J. Carvan III, K.C. Cheng, K. Crosier, P. Crosier, S. Ekker, A. Huttenlocher, K. Kawakami, G. Kelly, V. Korzh, G. Lieschke, M. Mione, M.N. Neely, S. Neuhauss, N.S. Trede. 2008. Views on four key questions about zebrafish research. Zebrafish. 5(1):9-24. Hutz, R.J., M.J. Carvan III, M.G. Baldridge, L.K. Conley, T. King Heiden. 2008. Environmental toxicants and effects on female reproductive function. Trends in Reproductive Biology 2:1-11. Weber, D.N., V.C. Connaughton, J.A. Dellinger, D. Klemer, A.. Udvadia, M.J. Carvan III. 2008. Selenomethionine reduces visual deficits due to developmental methylmercury exposures. Physiology & Behavior 93:250-260. King Heiden, T.C. C.A. Struble, M.L. Rise, M.J. Hessner, R.J. Hutz and M.J. Carvan III. 2008. Molecular targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the zebrafish ovary: Insights into TCDD-induced endocrine disruption and reproductive toxicity. Reproductive Toxicology 25:47-57. Carvan, M.J., III, E.P. Gallagher, A. Goksøyr, M.E. Hahn, D.G.J. Larsson. 2007. Fish models in toxicology. Zebrafish 4:9-20. Klaper R., C.B. Rees, P. Drevnick, D. Weber, M. Sandheinrich, M.J. Carvan. 2006. Gene Expression Changes Related to Endocrine Function and Decline in Reproduction in Fathead Minnow (Pimephales promelas) after Dietary Methylmercury Exposure. Environmental Health Perspectives 114:1317-1343. Arenzana, F.J., M.J. Carvan III, J. Aijón, R. Arévalo, A. Porteros. 2006. Teratogenic effects of ethanol exposure on zebrafish visual system development. Neurotoxicology and Teratology 28:342-348. Pullela, P.K., T.Chiku, M.J. Carvan, III, D.S. Sem. 2006. Fluorescence-based detection of thiols in vitro and in vivo using dithiol probes. Analytical Biochemistry 352:265-273. King Heiden, T., M.J. Carvan III, R.J. Hutz. 2006. Inhibition of follicular development, vitellogenesis, and serum 17β estradiol concentrations in zebrafish following chronic, sublethal dietary exposure to 2,3,7,8,-tetrachlorodibenzo-p-dioxin. Toxicological Sciences 90:490-s 90:49. [PubMed] King Heiden, T., R.J. Hutz, M.J. Carvan III. 2005. Accumulation, tissue distribution, and maternal transfer of dietary 2,3,7,8-dibenzo-p-dioxin: impacts on reproductive success of zebrafish. Toxicological Sciences 87:497-507, Advanced Access Publication, May 18, 2005. [PubMed] Carvan, M.J., III, E. Loucks, D.N. Weber, and F.E. Williams. 2004. Ethanol effects on the developing zebrafish: neurobehavior and skeletal morphogenesis. Neurotoxicology and Teratology 26:757-768. [PubMed] Loucks, E. and M.J. Carvan III. 2004. Strain-dependent effects of developmental ethanol exposure in zebrafish. Neurotoxicology and Teratology 26:745-55. [PubMed] Dasmahapatra, A.K., H.L. Doucet, C. Bhattacharyya, and M.J. Carvan III. 2001. Developmental expression of alchohol dehydrogenase (ADH3) in zebrafish (Danio rerio). Biochemical and Biophysical Research Communications 286:1082-1086. [PubMed] Carvan, M.J., III, D.M. Sonntag, C.B. Cmar, R.S. Cook, M.A. Curran, and G.L. Miller. 2001. Oxidative stress in zebrafish cells: Potential utility of transgenic zebrafish as a deployable sentinel for site hazard ranking. The Science of the Total Environment 274:183-196. [PubMed] Carvan, M.J., III, T.P. Dalton, G.W. Stuart, and D.W. Nebert. 2000. Transgenic zebrafish as sentinels for aquatic pollution. Annals of the New York Academy of Science, 919:133-147. [PubMed] Carvan, M.J.,III, W.A. Solis, L. Gedamu, and D.W. Nebert. 2000. Activation of transcription factors in zebrafish cell cultures by environmental pollutants. Archives of Biochemistry and Biophysics 376:320-327. [PubMed] Dalton, T.P., W.A. Solis, D.W. Nebert, and M.J. Carvan III. 2000. Characterization of MTF-1 transcription factor from zebrafish and trout cells. Comparative Biochemistry and Physiology 126:325-335. [PubMed]